Monday, November 05, 2007

day +76

Dr. Castro-Malaspina continues to be pleased with my progress. At my appointment, I learned that my blood counts remain good (WBC: 8.2; HGB: 13.4; platelets: 197).

My explanation a few days ago regarding the change in my Sirolimus dosage was wrong. It wasn't because of the high Creatinine level. Rather, as Dr. Castro-Malaspina explained to me today, the reduction in the dosage is due to his desire to begin to slowly taper down the immunosuppressive drugs so that my donor's T-cells will possess the needed mobility required to achieve the Graft-versus-Lymphoma (Hodgkin's) Effect. Of course, as he reiterated, the balance between GVL and GVHD is fine and narrow. So hopefully, this reduction in the dosage of the immunosuppressives won't expedite the risk of developing severe GVHD.

The written report of this morning's CT scan of my lungs should be available in 2-3 days.


Comment Blogger Jim Anderson said...

Duane, Makes sense about the donor T cells. I think there is technology to remove the donor T cells from the stem cell mix at day zero. But then you wouldnt get the GVL benefit. So now the docs will have you walk to tightrope between GVL and GVHD. I'm routing for you buddy! And I hope the CT scan results show no ground glassy areas.

8:00 PM  
Comment Blogger Duane said...

Thanks Jim!

5:09 PM  

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